Androgen receptors downregulation is a complete fallacy!
Lately, I have encountered a few inquiries regarding AR (androgen receptors) site saturation. Let me be clear, it is a myth that has been circulating for years and simply does not hold any truth. In reality, ARs do not down-regulate. There is no such thing as receptor down-regulation regarding AAS usage. In fact, with the presence of AAS/Androgens at a supraphysiologic level, they will up-regulate, continuously increasing and expressing new AR sites throughout the body and tissues. However, there are a few factors that can impede gains while on cycle, fueling the misconception of AR site saturation – Progesterone, Myostatin, and at times E1/E2 estrogen.
Regarding the AR
The AR gene’s primary function is to provide instructions for creating proteins known as androgen receptors. As we all know, androgens are hormones, with Testosterone being the most prominent. ARs enable the body to respond to these hormones, facilitating their direct actions such as muscle growth, recovery, and the development of male characteristics. Androgens bind to receptors distributed throughout the body and tissues, forming AR complexes that attach to DNA and regulate AR gene activity.
It is important to note that DNA is the only entity capable of turning the gene on or off, not AAS.
FYI – ARs are part of the NR (nuclear hormone receptors) gene family, which are proteins found within cells responsible for detecting steroid hormones. They also play a crucial role in maintaining homeostasis within the endocrine system.
Have you ever noticed that your gains start to fade after 10-14 weeks?
Well, fear not, my fellow fitness enthusiasts! This study I’m about to share with you might just have the answer to why our gains hit a plateau when using Test, deca/primo.
In my humble opinion, this is the perfect time to spice things up by adding an oral supplement like Dbol, drol, Tbol, Winny, or Var. These bad boys work their magic through a non-AR-mediated mechanism, unlike our old pals Testosterone, Deca, and Primo. They help differentiate the satellite cells of the muscle, giving those muscle cells a much-needed boost, all without relying on ARs.
So, next time you hit that 10-14 week mark and feel like your gains are slipping away, remember to shake things up with a little oral action. Your muscles will thank you!
In the final analysis,
I have concluded, based on my note, that AR down-regulation does not occur in the presence of androgens. It is also worth speculating that androgen receptors (ARs) serve as a constant binding site for the androgen ligand. This truth is supported by medical journals worldwide, which indicate that ARs actually up-regulate, increase, and continuously express new AR sites throughout the body and tissues.
Medical and scientific research shows that unbound androgen receptors have a half-life of about three hours before the body replaces them with new ones. However, when androgens bind to ARs, the receptors become more sensitive, their half-life doubles, and the body significantly increases the production of new receptors. It is crucial to note that AR-mediated effects are not the only factors influencing anabolic steroid activity in the body. There are additional effects, known as non-AR dependent effects, such as central nervous system stimulation and various anabolic activities.
Despite these complexities, the question remains as to why gains may slow down after a few cycles and why dosages need to be increased. The answer likely lies in the body’s attempt to achieve homeostasis through mechanisms other than the androgen receptor.
I hope this explanation sheds light on the subject and provides clarity.
Sincerely,
Team EP