Deca only cycles “NO! NO! NO!“
Interest is resurgent in a cycle concept revolving around NANDROLONE DECANOATE. This protocol, focusing solely on Nadrolone, is not as outdated as some may believe. In the past, during the golden era, individuals would run deca and Dbol cycles or Primo. But the evidence supporting these practices is largely anecdotal. The only substantial study comes from a small US military study.
When we delve deeper into this topic, it becomes apparent that there is an inherent estrogenic nature to nandrolone that cannot be effectively managed with an AI. But rather requires a SERM like Tamoxifen.
In more recent times, there have been individuals, primarily entrepreneurs living in Thailand, who have been promoting this concept. While some of their content is entertaining and backed by factual data, other aspects are merely experimental.
Now, let’s discuss this further! I appreciate the consideration of those who are exploring this idea and acknowledge the theory behind it. However, I am wary of those who are aggressively pushing this protocol onto users, downplaying the importance of testosterone and neglecting overall health. It is crucial to have a follow-up protocol in place to ensure the well-being of individuals.
Now, let’s address the elephant in the room –
My humble opinion. Who am I, you ask? Just a science and biology enthusiast who appreciates data-backed studies and trials. But let’s dive into the real issue at hand.
What grinds my gears about this Nandrolone-only protocol is the audacity of some individuals who claim that testosterone is solely responsible for estrogen production. Ridiculous, right? Genetics, aromatase enzymes, and body fat composition all play a role in estrogen levels. And let’s not forget about those sneaky estrogen mimickers lurking in the shadows.
Remember the aromatase enzyme?
It’s the real MVP when it comes to converting testosterone into estrogen. And don’t even get me started on testosterone transforming into DHT through the magic of 5-alpha reductase. DHT reigns supreme as an androgen receptor agonist, making it a force to be reckoned with compared to our pal NANDROLONE (DHN).
Testosterone, on the other hand, has multiple tricks up its sleeve – from converting into estrogen to staying true to its testosterone form.
But what about Nandrolone?
It simply transforms into DHN… What’s that, you ask?
Well, we’ll get into that shortly.
The elephant in the room, let’s talk about it…
This is a case-by-case situation, where individuals face off against each other, rather than a one-size-fits-all approach to life. Some guys can take 1g of test and stay as dry as a bone. while others blow up on 400 mgs.
Why is that? Genetics, my friends!
Let’s ponder this for a moment. Without trying to sound too conservative, there are several good reasons why this isn’t the brightest idea. Testosterone/estrogen ratio issues have been studied and addressed countless times with a more sophisticated biomedical perspective, unlike this blunt, unwavering ideology.
This theory lacks a solid foundation for its information, gathered and pieced together for what purpose? Just because it can be done, if done correctly?
That’s just plain silly, for a bunch of silly geese acting like silly geese.
Relying solely on Deca is not a recommended protocol. It’s more of a personal experiment to see who lucks out or not with Deca alone. Progesterone blockers won’t do much against gyno caused by nandrolone decanoate (Tamoxifen and its counterpart Raloxifene would be the best targeting drugs). So, let’s not put all our eggs in one Deca-filled basket, shall we?
As mentioned prior, Testosterone has three main actions: converting into estrogen, remaining as testosterone (its primary function), or converting to DHT.
Ever wondered what nandrolone converts to? DHN…
What’s that?
Well, DHN binds to the same receptors as DHT, but with much less potency. When DHT is removed or reduced, DHN takes over the receptors. This can lead to issues like erectile dysfunction and feminizing side effects. As our system gets flooded with a synthetic progestin. It increases prolactin serum levels and affecting progesterone receptors and pituitary functions.
Moreover, Nandrolone does indeed convert into estrogen through various pathways, even though medical science has been misled into thinking otherwise. This confusion dates back to the 70s. But do we still churn butter in a wooden vat like they did back then?
Check out the following read for a deeper dive into this topic and shed some light on the misconceptions surrounding nandrolone’s conversion processes. Let’s not get stuck in the past, it’s time to update our knowledge and move forward.
While they may have a point (kinda), let’s face it – do we NEED tests? Sure, biologically, it can help keep a guy healthy and functioning as intended from creation. But these guys are going all out on a theory involving a man-made substance. That’s only found in tiny amounts in humans, trying to push Testosterone aside (which has been ruling the roost for hundreds and thousands of years of evolution) and suddenly saying, “Nah, you don’t need it?”
There’s a perfectly good reason why tests are essential. Exogenous testosterone isn’t our own – some folks might not react well to it. Experiencing an immune (allergic-like) response to certain esters. But let’s not dive into that rabbit hole. Think of an exogenous test like a glove – it fits on your hand, moves with your hand, but it’s not your real hand. And this glove lacks a key signature trait, like fingerprints. These fingerprints I’m talking about are the unique chemical messages our natural test sends, triggering different responses because it’s yours. It’s like getting a transplant and your body rejecting it because it’s not yours – it might work for some, but not for others.
So, don’t mess with your body’s bacon or the honey bee from nature… Seriously, where am I getting at here? Keep reading –
Before we dive into the best part, here’s my final thought on this topic: Removing a Test is like taking a bee out of nature. And we all know what happens when you mess with the bees – things get a little stingy.
There is absolutely no advantage to running Nandrolone at supratherapeutic dosages without including exogenous testosterone. A SARMS stack would be a much better option for those considering skipping the test and avoiding other AAS.
In my humble opinion
It’s crucial to understand that hormones, especially testosterone, are like chemical messengers sending important signals to cells with specific receptors. These signals can directly change genes, activate pathways, and set off a chain reaction of events within the body. Testosterone has its own unique biosynthetic pathways that can’t be replicated by any other substance. Even at a replacement dose, testosterone is essential for maintaining proper balance and checks in the body. Removing it would be like taking a bee out of nature – things just wouldn’t work the same.
The effects of hormones can vary greatly depending on factors like genetics, age, and ethnicity. Hormones have complex pathways that occur within the endocrine system, either before or after reaching their target tissues. It’s a fascinating dance of activation, inactivation, and elimination that keeps our bodies in check. So, remember, when it comes to hormones, it’s best not to mess with nature’s delicate balance.
Many hormones are metabolized within their target tissue, where a complex interplay between activation and inactivation mechanisms regulates the specificity and amplitude of the hormonal response.
Think of testosterone (T) as the star of the show – always there, shining bright. Other compounds are like the supporting cast, playing their roles perfectly. But taking out T and replacing it with something else is like tossing a perfectly good piece of crispy bacon in the trash and trying to pass off some synthetic imitation.
Why would you do that? Your body craves T just like you crave bacon. Don’t deprive your endocrine system of its favorite treat!
Many people are fascinated by the extreme practices of professional athletes when it comes to using anabolic steroids (AAS) to achieve elite levels of mass and power. However, the reality is that most AAS users are not as extreme in their approach. Instead, they tend to opt for cycles that are convenient and reliable.
One classic cycle that has been popular for decades is “Deca & D-bol,” which refers to nandrolone decanoate and methandrostenolone (Deca-Durabolin and Dianabol). Many recreational AAS users have praised this cycle for its convenience, effectiveness, and affordability. Despite its familiarity, it remains a go-to choice for many.
D-bol, known generically as methandrostenolone, is favored for its ability to provide rapid gains in strength and mass. However, it does come with some side effects such as acne, irritability, and hair loss, especially at higher doses. Women who use D-bol are at a high risk of experiencing masculinizing side effects like facial hair growth, deepening voice, and clitoral hypertrophy.
It is crucial to be aware that D-bol is a 17á-alkylated steroid. Which means it can potentially cause liver damage, including rare cases of liver tumors, malignant cancers, or cysts. These risks underscore the importance of using AAS responsibly and being informed about the potential health consequences.
Deca, a term used generically for many nandrolone products,
It is truly a game-changer in the world of bodybuilding. Unlike other steroids, Deca may take a bit longer to show results. But when it does, the gains are top-notch quality. Even though the effects may not be as dramatic, they are worth the wait.
One of the best things about Deca is that it carries a lower risk of androgenic effects in males. Despite its strong binding to the androgen receptor. Deca is converted into a less androgenic metabolite by the enzyme 5á-reductase. Which is known for causing issues like hair loss and prostate enlargement. This means that impotence and loss of libido are rarely associated with Deca, making it a popular choice among AAS users.
To enhance the effects of Deca, many users combine it with an androgenic AAS like D-bol. This combination is considered to be the perfect balance of two complementary drugs, ensuring optimal results without any unwanted side effects. Deca and D-bol together create a powerful synergy that can take your gains to the next level. Get ready to transform your body and achieve your fitness goals with the incredible benefits of Deca – but NOT without testosterone (T)!
Side Effect
One common side effect that can occur in many AAS cycles, including the popular Deca and D-bol cycle, is gynecomastia. Gynecomastia is the abnormal growth of breast tissue in males. This condition can occur during puberty, later in life, in cases of obesity, and with the use of certain drug therapies such as antipsychotics, anti-androgens for prostate cancer, and excessive AAS use.
When gynecomastia occurs during a cycle that includes Deca, it is often attributed to other drugs in the cycle, as Deca is thought to be resistant to aromatization. However, in the case of the classic Deca and D-bol cycle, this assumption may not hold. Methandrostenolone (D-bol) can produce a potent estrogen as a by-product, which could contribute to gynecomastia.
Despite its reputation, nandrolone (Deca) is not typically used alone in cycles due to its mild effects on muscle size and strength compared to other AAS. When used without stacking with other AAS, Deca cycles are usually low to moderate in dosage (200 mg- 600 mg/week). Side effects in adult males are generally minimal, except for potential impotence and decreased libido.
In conclusion
Gynecomastia is a potential side effect to be aware of in AAS cycles, including those involving Deca. It is important to understand the risks and benefits of each drug used in a cycle to minimize the likelihood of experiencing unwanted side effects.
Nandrolone interacts with both the androgen receptor and progesterone receptors, leading to potential impacts on fertility and sex drive. Progesterone, a female hormone similar to estrogen, plays a role in this interaction. In the pharmaceutical industry, steroid-based contraceptives for men often combine an androgen (like long-acting testosterone) with a progestin to achieve contraceptive results without significant side effects. While high doses of androgens can lower sperm counts, extremely high concentrations of testosterone are needed to completely shut down sperm production, and the effects vary among individuals.
Using an androgen and a progestin together has been found to provide consistent contraceptive results without causing significant side effects. Nandrolone, capable of activating both androgen and progestin receptors, can impact fertility and sex drive when used in supraphysiologic doses. Natural testosterone production is quickly suppressed with nandrolone use, and it may take weeks to months after stopping use for normal production to resume. Therefore, experienced users of anabolic-androgenic steroids often include post-cycle support, such as hCG and/or Clomid, at the end of a cycle that includes Deca.
Nandrolone is not just your average steroid
It’s a real multitasker. Not only does it cozy up to androgen and progestin receptors, but it also has the potential to transform into estradiol, the Beyoncé of natural estrogens. This has caused quite a stir in the scientific community, as the process of nandrolone’s metamorphosis has only recently been unraveled.
While testosterone and androstenedione are like the popular kids at the aromatase reaction party, nandrolone is more of a wallflower. It’s not typically found in large quantities in human males, and even when it does show up, it’s in such small amounts that it won’t raise any eyebrows on a drug test.
Nandrolone seems to be the black sheep of the aromatase family, a flawed product that the body doesn’t really know what to do with. It’s like the factory reject that somehow made its way onto the production line.
So, next time you hear about nandrolone and its sneaky ways, just remember – it’s the oddball of the steroid world, trying to fit in but always standing out.
There seems to be quite a bit of confusion swirling around the topic of nandrolone and its aromatization concerning steroid use. Despite claims from reputable researchers in top-notch scientific journals that nandrolone is a non-aromatizable steroid, a closer look at the research reveals some interesting findings that shed light on the matter.
The process of aromatization is no walk in the park
It’s a complex, multi-step pathway involving a variety of enzymatic reactions. This aromatase reaction isn’t picky either, showing up in different tissues like the brain, ovary, adipose, placenta, and even in various species like humans, horses, pigs, and yes, even bacteria. Talk about a diverse crowd!
The real kicker here is that the aromatase enzyme (cytochrome p450arom) is a chameleon, with bacterial aromatase looking nothing like its mammalian counterpart. And don’t even get me started on the differences between pigs, horses, and humans – it’s like trying to translate Shakespeare into Klingon.
To add to the confusion, different tissues within the same species can have different promoters that control enzyme production. So, what promotes aromatization in the testes might not be the same as what gets those fat cells in on the action.
In conclusion
The world of aromatization is a wild and wacky place, full of twists and turns that keep even the most seasoned researchers on their toes. So, next time someone tries to tell you nandrolone is a non-aromatizable steroid, just remember – the truth is a lot more complex and intriguing than meets the eye.
In mammals, the aromatase reaction involves two distinct enzymes working together to convert androgens into estrogens. The first enzyme, known as the hemoprotein CYParom and encoded by the CYP19 gene, acts as the catalyst in this process. It targets the 19-carbon in two steps and the nearby 1-carbon by oxidizing the androgen molecule at those specific points. The subsequent actions of the second enzyme, NADPH-cytochrome P450 reductase, result in the removal of the 19-carbon and the simultaneous creation of a phenolic A-ring, a key characteristic of estrogens. In cases where the 19-carbon is absent, as seen in nandrolone, the efficiency of the reaction is significantly reduced, if it can occur at all.
Numerous medical and scientific journals
Identified nandrolone as a non-aromatizable AAS. Research conducted on brain cells has demonstrated that nandrolone is more neurotoxic due to its inability to undergo aromatization. It is important to note that nandrolone cannot undergo classic aromatization, as the missing 19-carbon is essential for initiating the aromatase reaction. Interestingly, nandrolone has been found to stimulate aromatase in rat models, despite not directly participating in the reaction. This stimulation could potentially accelerate the conversion of other androgens, such as testosterone and D-bol.
The findings of a recent study published in the Climacteric have shed light on the fascinating transformation of nandrolone and other 19-nortestosterone-derived steroids into estrogenic steroids within the human liver. It turns out that through a series of enzymatic reactions, these steroids can undergo a magical metamorphosis.
CYP 450arom
The first enzyme in this enchanting process, CYP 450arom, may not be hanging out in the adult human liver, but fear not! Another enzyme, CYP 450 monooxygenase, swoops in to save the day by attacking the 2-carbon of nandrolone and kickstarting the creation of the phenolic A-ring. This is the crucial step in the alchemical conversion of an androgen (or 19-norandrogen) into an estrogen.
So, next time you hear someone talking about nandrolone and its estrogenic potential, you can impress them with your newfound knowledge of the liver’s secret enzymatic powers. It’s like a science fiction story unfolding right inside our bodies!
Remember when the CYP 450 arom was the star of the show, speeding up the classic aromatase reaction like a champ? Well, the CYP 450 monooxygenase is like the slowpoke of the group, not nearly as efficient. This explains why nandrolone only aromatizes at about 20 percent of the rate of testosterone or androstenediol. Or maybe even less, who knows?
Now, let’s talk about Deca.
It’s injected into your muscles and takes its sweet time dispersing. The enzyme system we discussed in that Climacteric article? Yeah, that’s specific to the liver. So, it’s pretty unlikely that your standard nandrolone-containing cycles would have a major contribution to feminizing effects from nandrolone being aromatized.
But wait, there’s more! Back in the prohormone glory days, oral norandrogen precursors were all the rage. And now, there’s an oral norandrogen (7á-methylnortestosterone) in the works as a potential male contraceptive. At high doses, these oral norandrogens could potentially mess with your estrogen levels enough to cause gynecomastia or other estrogen-related issues.
For women taking oral
Norandrogens for menopause, researchers think there’s a chance these drugs could increase estrogen levels and up the risk for clotting problems or estrogen-sensitive cancers. So, maybe think twice before popping those pills, folks.
Nandrolone is often seen as the golden child of AAS, beloved by bodybuilders and power athletes alike. It’s like the cool kid at the gym that everyone wants to hang out with. While it’s generally considered safe, there are some sneaky side effects to watch out for.
You see, nandrolone may not play well with estrogen
Sure, it doesn’t typically cause estrogen-related issues like some other steroids do, but it has a few tricks up its sleeve. It can mess with progesterone receptors and kickstart a secondary aromatase reaction, leading to potential problems like gynecomastia (aka man boobs) and a delay in getting your natural testosterone back on track post-cycle.
And if that wasn’t enough, nandrolone can also speed up the classic aromatization process of testosterone and other androgens. So, if you’re popping oral forms of nandrolone like they’re candy, you might be in for a wild ride. These bad boys have a higher estrogenic index and a greater risk of estrogenic side effects, thanks to some liver shenanigans.
So, while nandrolone may be the popular kid in the AAS world, it’s always good to keep an eye on its mischievous behavior. Stay safe, stay swole, and remember – not all that glitters is gold in the world of steroids. – USE (T) WITH YOUR NANDROLONE CYCLES – PERIOD!